Research & Development

Animal Ethics

Ono's Ethical Considerations in Animal Experiments

Ono is wishing to make social contribution by developing drugs that support the healthy lives of people. However, in the process of new drug discovery, experiments on laboratory animals are imperative. From the viewpoint of animal welfare, we believe that the lives of laboratory animals must be respected and their distress minimized, conducting scientifically rational experiments with the minimum number of animals.
To this end, Ono follows in-house regulations in complying with Japan's Act on Welfare and Management of Animals and the related guidelines. We have also established the Institutional Animal Care and Use Committee that reviews whether all animal experimental protocols are prepared based on "3Rs principles" *1 in advance, and implements self-inspections and assessments of the animal experiment processes and the facility operations. In addition, Ono has earned the Center for Accreditation of Laboratory Animal Care and Use (CALAC)*2 accreditation as an animal testing facility.

*1) 3Rs principles: Replacement (active use of alternative methods of experiment), Reduction (reducing the number of test animals) and Refinement (alleviation of pain)
*2)CALAC is an organization within the Japan Health Science Foundation that conducts third–party inspections and evaluations of animal experimentation and other work at animal testing research institutions under the jurisdiction of the Ministry of Health, Labour and Welfare. CALAC determines whether such facilities are conducting appropriate experiments based on a scientific perspective, while promoting voluntary ethics management of animal testing programs and consideration of animal welfare.